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What is ovarian rejuvenation (PRP), and how can it help me?

4 fertility expert(s) answered this question

Answer from: Laura García de Miguel, MD

Gynaecologist, Fertility Specialist
Clinica Tambre

Ovarian PRP treatment is an experimental strategy that we use for patients having low ovarian reserve, with a not very advanced age, and it consists of extracting blood, peripherical blood, concentrating and using growth factors, and injecting it into the ovary. With this treatment, we try to make the antral follicles more competent, and more active to the medication and try to have a higher response in the following months. Again, this is experimental but there is evidence in many articles revealing that it could help to improve the outcome in patients with ovary insufficiency and poor ovarian reserve.

Answer from: Diana Obidniak, MD

Gynaecologist, Director
Art of Birth Clinic

Platelet-rich plasma (PRP) is becoming more and more popular as a non-surgical treatment option for a broad spectrum of medical disorders. The theory underlying this method was derived from a natural healing process. The body’s first response to tissue injury is to deliver platelets to the injured area. Platelets promote healing and attract growth factors to the site of injury.

In reproductive medicine, PRP therapy is developed in different directions. The first one refers to the so-called ovarian rejuvenation for women with premature ovarian failure and patients with low ovarian reserve. During this procedure, PRP is injected into the ovary under ultrasound guidance, similarly to egg retrieval in the IVF cycle. However, this type of treatment is still under investigation.

Thus, it cannot be recommended in routine practice. Nevertheless, the PRP treatment in the mode of intrauterine infusions has been implemented as an inspiring strategy for patients with recurrent implantation failure and women with a resistant thin endometrium.

Answer from: Alejandro Aldape Arellano, MD

Gynaecologist, (Former clinic) Medical Director
Institut Marquès

PRP, which is plasma rich in platelets for ovarian rejuvenation, is still more hope than reality.

Nowadays, there is no way of fixing a diminished ovarian reserve. We have been trying several supplements, like DHEA or testosterone, with very limited success. Also, the PRP hasn’t been proved to be completely safe for patients. So the bottom line is that the PRP is still experimental.

Answer from: Inna Moroz, MD

Gynaecologist, Fertility Specialist

PRP or platelet-rich plasma therapy is using the patient’s own concentrated platelets (with a high number of growth factors) into ovaries by a laparoscopy. Platelets are specific blood cells that are responsible for blood clotting out of the small injury. That’s why, in the past, the injection of PRP was used in medicine for the acceleration of the healing process of injured tendons, muscles, or joints.

Now, some doctors are using this method experimentally to rejuvenate the ovaries, especially in women who have premature menopause. As the experimental technique, its use, for safety and effectiveness requires more investigation and more clinical study. That’s why today, we do not recommend using it as a tool for infertility to our patients.

About this question:

Is ovarian rejuvenation a solution for me?

Platelet-rich plasma (PRP) is becoming more and more popular as a non-surgical treatment option for a broad spectrum of medical disorders. How can it be used in case of infertility? How is it performed? Who can use it? And is it effective at all?

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