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A genetic condition occurs when a gene and the X chromosome has a variation – this is called x-linked inheritance. We should remember this X-linked dominant gene is a gene located on the X-chromosome and may affect males and females differently. This type of inheritance refers to the inheritance of a gene variant on the X chromosome males. Typically they have one X chromosome and one Y chromosome whereas female people typically have two copies of the X chromosome and no Y chromosome because of this, males will only have one copy of each X chromosome gene while females will have two. In the case of females, although each body cell has two X chromosomes, only one is used for making the gene product and the other X chromosome is switched off. This process of switching off is known as X inactivation so, this usually happens randomly in some of the female cells one particularly X will be inactivated or switched off and in another cell that X will be will be active for switch on if DNA change occurs in only one copy, just one copy of the pair of genes and this causes a health conditions that is called a dominant variant.
Answer from:
X-linked dominants are incredibly rare, thankfully. I had to look this one up. Only four different genes are X-linked dominant. An example is the PDK 3 gene, which causes a disease called Charcot-Marie-Tooth Disease, which affects the peripheral nervous system, leading to muscle weakness. Fortunately, there are no known X-linked dominant genes that affect fertility. I think if they were about males would be incredibly infertile.
