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Should PGT-A / PGS be used to test embryos developed from donor’s eggs?

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2 fertility expert(s) answered this question

Answer from: Saghar Kasiri, Clinical Embryologist

Embryologist, Director of European Operations Cryos International
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Using any kind of genetic screening to check embryos that are coming from egg donation, it’s not proven to be necessary all the time. Unfortunately, some clinics may routinely offer this but let’s think about it, the eggs are young, these are young, healthy eggs that are being used, so as long as the sperm is normal. The research doesn’t show any benefit to add any kind of genetic screening for those embryos. The concern comes in if we have also got some issues with the sperm, so if the sperm, for example, has got high uneuployed rates or abnormality rates, chromosome unemployed rate, it can be beneficial maybe if needed in the previous IVF cycles it’s been shown that there has continuously been a very poor development of embryos or many miscarriages, then it could be beneficial but routinely it is really not needed if the sperm quality is good and the egg equality from a young donor is also good, that there is no need to do it.

Answer from: Dimitra Christopikou, Clinical Laboratory Geneticist

Geneticist, Head of the PGT lab Embryogenesis IVF Unit Athens
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There are not many papers out there but two or three say that this does not help at all. Most of the papers show the donor eggs come from younger women so we take out the factor that really aids the egg and tends to create chromosome abnormalities. When we take out this factor we don’t really have a good indication to take this test. However there are some labs in the United states that are performing this test in donor eggs but most of these trials don’t show any benefits from it.

About this question:

Why should we also test embryos coming from the donor's egg?

What are the main indications for genetic testing? Does testing embryos created from donors make sense?

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15 articles & 68 pages of "All About IVF"