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What does it mean if you have a mitochondrial DNA gene mutation?

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2 fertility expert(s) answered this question

Mitochondrial DNA gene mutations - what are they?

What are mitochondrial DNA gene mutations and how can they affect the health and fertility of men and women?

Answer from:
Gynaecologist, Gynaecologist in Reproductive Medicine & Reproductive Genetics Clínica Monterrico
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Answer from:
Geneticist, Co-Founder & Chief Scientific Officer Fertility Genomics
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If you’ve got mitochondrial gene mutation, in particular genes, it may affect the motility of the sperm because the mitochondria are vital for generating the power for the tail to move. So if you’ve got mutations in the mitochondria and they’re not working as well, the batteries aren’t driving the tail motion so that it can affect male fertility.

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