English  |  Deutsch 

What is PICSI?

3 fertility expert(s) answered this question

Answer from: Alexia Chatziparasidou,  MSc, PMI-RMP

Embryologist, Consultant Clinical Embryologist, Director of Embryolab Academy, Co-Founder of Embryolab Fertility Clinic Embryolab Fertility Clinic
play-video-icon-yt

PICSI is another one of the new tools which use a chemical substrate that allows the more mature forms of spermatozoa to stick and hence, it gives us a way to further select our spermatozoa – not only based on their morphology but on the ability to stick on this special substrate chemical substrate which indicates the higher maturity status. When using PICSI, we aim to advance our sperm selection and hence, advance the prognosis and improve the prognosis and chances for a better outcome. However, there are still contradicting results on what the clear benefit when using PICSI is and for which patient PICSI is more indicated. So, we still have challenges linked to the use of PICSI.

Answer from: Andrea Sánchez Freire

Senior Embryologist ReproMed Ireland
play-video-icon-yt

So PICSI is the same as ICSI but in this case, we select the sperm into a dish with hyaluronic acid, and we select the sperm that are mature. So in this case we only have the mature sperm to get into the egg, so we make sure that the sperm is mature.

Answer from: Michael Carroll, BSc, PhD, PgCAP, CBiol, FRSB, FIBMS, FHEA, FLS, ANSHCS

Embryologist, Reader (Associate Professor) in Reproductive Science at Manchester Metropolitan University
play-video-icon-yt

PICSI is an acronym stands forPhysiological Intracytoplasmic Sperm Injection and it’s a way of selecting sperm by its capacity to bind to hyaluronic acid. So it’s a type of selection procedure for sperm based on its ability to bind to this particular molecule and those sperm that do that are believed to be more physiologically important for the sperm binding to an egg for instance. There’s been a lot of trials, clinical trials to demonstrate the use-fullness of this in IVF however, none of them to date have demonstrated that it does lead to or increase the chances of a live birth during the procedure. So the jury is still out on this and it’s considered a red on the HFEA traffic light system for the add-on procedures.

About this question:

What does PICSI stand for?

How is PICSI done? What is the difference between ICSI and PICSI?

Find similar questions:

Related questions

What are the risks of TESE?

Michael Carroll

 

Michael Carroll, BSc, PhD, PgCAP, CBiol, FRSB, FIBMS, FHEA, FLS, ANSHCS
Embryologist

+ 3 more answers

Watch answers »

What is TESE in IVF?

Tomas Frgala

 

Tomas Frgala, PhD
Gynaecologist

+ 1 more answers

Watch answers »

How long does a sperm retrieval procedure take?

Saghar Kasiri

 

Saghar Kasiri, Clinical Embryologist
Embryologist

+ 3 more answers

Watch answers »

Are there any other reasons to perform TESA?

Saghar Kasiri

 

Saghar Kasiri, Clinical Embryologist
Embryologist

Watch answers »
Fertility Road Magazine
The only magazine for patients devoted to IVF treatment.
15 articles & 68 pages of "All About IVF"