Answer from: Dimitris Papanikolaou, MD
I will speak only according to my personal observations. I have over 1000 patients that I have monitored their immune system before and during the pregnancy and some of them after the pregnancy. The many common complications during pregnancy are the immune system, I have noticed that the women that had treatment for the immune system have less chances of those complications, heavier babies and less chances of giving birth earlier. Few characteristics of women who managed to get pregnant but they still have immunological problems is that they have complications during pregnancy – preeclampsia (nobody knows from where it comes but everybody suspect immune system) or early labour, spontaneous rupture of membrane all those things are related in one or the other way with immune system.
At the beginning when I made plans to support implantation mainly, I managed to make some women pregnant, then I realised that most of my patients started giving birth earlier (at 32, 33, 34 weeks of pregnancy). I wondered why it was happening? Then I realised that the immune system shouldn’t be “stopped” at 12 weeks, it is still working. As one of the first, I started to support pregnancy with medications until the end. With that way, basically, from my statistics (I insist on that), I saw that my patients they have less chances of this complications, they give birth later, I have less spontaneous rupture of membranes and what is the most important, I have less problems after the flare up that happens when they give birth.
Answer from: Ioannis John Toliopoulos, PhD
No, not at all because intralipids were one of the first discoveries of my professor who trained me in the United States so it is about more than 20 years and I have been doing it the last 10 years very easily and we had no negative outcome. If the problem is elevated NK cells, we block the receptors of the NK cells so we block the activity and this way we see the decrease of the NK cells ratio if it is too high. We block the endometrium from the NK cells and also the peripheral NK cells. Also, intralipids cannot have any side effects because it is not just a direct solution of intralipid – it is a combination like cocktail with natural serum, natural sodium chloride 0.9% means no side effects. In the run of the infusion it is only 30 minutes so the patient doesn’t need to stay for 2-3 hours to do the infusion and have side effects and have to go slowly. We have timeded. The normal flow of the infusion of 250ml of sodium chloride 0.9% plus the specific solution we give depending on the diagnostic test result makes the dosage individualized and targeted and block the NK cells significantly and we had never had any side effects from the intralipids. This is because it is a fatty motion solution and not any drugs and it is nothing like that.
