Answer from: Douglas Lester, PhD, MSc, BSc (Hons)
Small letter and changes like letter swapping, small deletions, or insertion can only really be picked up by this modern technique, which has been around the last ten years or so, called Next Generation Sequencing. For example, our company Fertility Genomics uses the most economical method known as Exome Sequencing or Whole Exome Sequencing. This is capable of picking up at least 85% of all DNA mutations. Following that, our unique statistical analysis can then predict with 99% accuracy whether DNA change is likely to affect IVF cycles.
