Answer from: Raúl Olivares, MD
The main problem with progesterone levels in IVF is that they can be really different, and of course, it is related to the number of eggs and the number of follicles you’ve produced. Nowadays, the levels of progesterone are being tested. We are trying to find out the correct levels in cases where the conditions are very similar, for example, in cases of cryotransfers, in egg donation, and if the patients are in hormone replacement therapy. In such cases, the conditions are quite strict, and you can repeat the same conditions in future cycles. In these cases, there are even some differences between some groups, we accept that progesterone levels, I would say over 9.2 -10.2, are the cut-off point. In cases, where the levels are lower than this, we recommend adding some subcutaneous progesterone to vaginal pessaries.
In IVF, I wouldn’t say that there is no reference at this point, and it depends a lot on the number of eggs, as I’ve mentioned. Levels of progesterone that are over 15-16 are quite common. However, there is no advantage, for example, to take intramuscular progesterone that is going to increase your levels to 50-54. Keep in mind that the units can be confusing sometimes, as progesterone can be measured in nmol/L or ng/Ml, so we need to be aware of that. In our case, we use ng/ml, so if your levels are over 15-16 ng/Ml, you can be absolutely relaxed because the levels are never going to be a problem.
What is the optimal level of progesterone when preparing for an IVF? May it vary because of other parameters?
Why is progesterone important in IVF? Many scientific studies have shown that when progesterone was used during IVF cycles, the rates were much higher compared to cycles without it. What is a good level of progesterone during IVF cycles? What kind of progesterone should I take during IVF?