Answer from: Raúl Olivares, MD
As with any other technical procedures in medicine, PGS makes sense where there is a medical indication. That’s very important because it is an invasive procedure. We’re going to make a hole in the embryo, we’re going to take cells, and though most of the studies confirm that it’s a completely safe procedure for their health, whenever we may avoid manipulating the embryos, we should do it.
We currently recommend PGS when there is a higher risk of having genetic issues in the embryos. This is in cases where the patient is of advanced age, over 40, where there have been recurrent miscarriages, where there is some kind of genetic abnormalities. Either because the karyotype is abnormal or there is a severe male factor, which has also been related to a higher risk of having problems with the sperm.
In all those cases, it may make sense because we’re going to discard a lot of embryos. If you are doing, let’s say, a double donation, so you’re using donor sperm and an egg donor, PGS does not make any sense because most of the embryos are going to genetically normal.
Answer from: Luca Gianaroli
It is useful because you reduce the time to pregnancy, and you avoid unnecessary transfers. You avoid the stress of miscarriages. You avoid wasted months, mainly with advanced maternal age, so three or four months for a miscarriage or termination of pregnancy and then the psychological time to recovery. The psychological time to start again can be extremely detrimental for patients over the age of 37-38. So this is the first important advantage.
The second advantage is that you avoid doing clinical procedures that you know will not bring the success you are looking for from an ethical point of view. Whether these clinical procedures are undertaken in a private or public centre, reducing the money spent to generate an individual will benefit everybody.