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How TESE and PESA differs from each other?

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2 fertility expert(s) answered this question

What is the difference between PESA and TESA?

Male factor is one of the reasons for proceeding with ART. Nowadays, there are several techniques that help in obtaining sperm directly from testicles. What are some of them?

Answer from:
Embryologist, Consultant Clinical Embryologist & Laboratory Manager Centre for Reproduction and Gynaecology Wales (CRGW)
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TESE is where you are essentially a testicular biopsy where you cut with a scalpel cut directly into the testicles and remove tissue directly from it. Sometimes it’s done with the use of a microscope so they look for what look to be the best tubules in the testicles. PESA is where you put the needle directly into the epididymis and aspirate and the epididymis is where the sperm is stored normally, so if you produce sperm it’s just an access issue you’ll in most cases get sperm directly that way.

Answer from:
Embryologist, Reader (Associate Professor) in Reproductive Science at Manchester Metropolitan University
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They are both acronyms for surgical sperm retrieval techniques. TESE is testicular sperm extraction and PESA is Percutaneous Epididymal Sperm Aspiration. The latter, the PESA is a less invasive procedure. It’s where the physician will take a needle and inject the epididymis and extract sperm and fluid within the epididymis to remove, to recover sperm from that particular area of the testes. It’s usually the first step during the surgical sperm retrievals and if sperm cannot be found in a PESA, then move on to TESE. In case of non-obstructive azoospermia (that is where sperm is not produced in the ejaculate) normally, it’s TESA or TESE or microTESE that physicians will do. TESE is more invasive, it’s testicular sperm extraction. It’s where extractions of testicular tissue are removed from the testes and then the sperm is recovered from those tissue extractions. PESA is less invasive and sperm can be recovered, TESA is more invasive and both in both cases sperm can be recovered and used for the IVF process.

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