Answer from:
Although for many years it was thought that once we have reached a certain number of eggs, the quality of those eggs could not be as good as in a natural cycle, this theory has now been abandoned. There are many studies that discuss the so-called cumulative pregnancy rate, which refers to the chances of getting pregnant with at least 1 of the embryos produced in that cycle. According to these studies, we know that patients who produce more eggs are likely to have more embryos, and with more embryos, there are more chances of success, perhaps not in the first fresh embryo transfer, but in subsequent frozen embryo transfers.
Answer from:
Speaking of hyperstimulation, we can say that it does not affect the egg quality. We know now that it is a separate situation. When we receive the eggs in the laboratory, we move forward with creating the embryo’s, which are good quality, in order to transfer. This is parallel with OHSS syndrome. We must then take care of the patient, to make sure that she is okay to have an embryo transfer. But it does not actually affect the oocyte or embryo quality at the end of the day.
Answer from:
There’s not really a really strong correlation between OHSS and oocyte quality. However, there’s probably a much stronger correlation between oocyte quantity and OHSS risk, so the more eggs you have, the higher the risk of OHSS and that’s because OHSS can be made by the vascular endothelial growth factors be made by all these follicles and so the more follicles you’ve got the more VEGF you’ve got and that causes you to have these kind of fluids abnormalities within peritoneal cavity. I wouldn’t necessarily say that you’ve got a bad outcome in terms of overall success rates if you’ve had the OHSS and because of the quality effect, but it certainly is associated with quantity and that’s why we often use a number of eggs retrieved as a marker of risk to further refine risk and think about using do we need to proceed with the “freeze all” particularly in these days of COVID where we won’t want to place further burden on NHS.
