Free Download
Fertility Road Magazine
The only magazine devoted to IVF and donor conception!​
15 articles & 68 pages of "All About IVF"

English  |  Deutsch 

Do natural killer cells cause miscarriage?

Category:
3 fertility expert(s) answered this question

Answer from: Andrew Thomson, FRCPath

Embryologist, Consultant Clinical Embryologist & Laboratory Manager Centre for Reproduction and Gynaecology Wales (CRGW)
play-video-icon-yt

The theory would be that if you have high natural killer cells, you’re either at a higher risk of miscarriage or you’re at a higher risk of recurrent implantation failure which is you’re putting back multiple good quality blastocysts over several cycles and still not getting pregnant. If you’re diagnosed with uterine high natural killer cells, there are different treatment options depending on what clinic you go to. The most common approach is to give you pregnazole which will reduce the amount of natural killer cells and theoretically improve your chances of implantation and reduce your chances of miscarriage but the evidence is probably weak at best and again should only be done by sort of a center that specializes in that kind of area.

Answer from: Dimitris Papanikolaou, MD

Gynaecologist, Founder and Clinical Director at Life Clinic Athens
play-video-icon-yt

Answer from: Orestis Tsonis, MD, MSc, PhD

Gynaecologist, Specialist in Reproductive Medicine at Guy’s And St Thomas’ Hospital NHS Foundation Trust
play-video-icon-yt

Accumulating data suggests that the mechanisms underlying recurrent pregnancy loss are driven by immunological dysfunction. In the literature, repeated implantation failures and recurrent pregnancy losses, although pathophysiologically and immunologically different, tend to overlap. Studies have shown that distinct uterine NK cell populations might promote pro-inflammatory rather than anti-inflammatory pathways that could result in poor obstetric outcomes. In women suffering from recurrent pregnancy loss this secretion of Interleukin-10 inhibits (IL-10) and interferon gamma, was decreased due to a general decrease of decidual NK cells. Moreover, an increase in the number of decidual NK cells is also noted in such cases. A metanalysis has illustrated the increased percentage of peripheral NK cells in women with recurent pregnancy loss underlying that any abnormality in their number could potentially cause miscarriage. The decidual NK cells through the regulation of immune response, create an immunosuppressive environment favouring the placental invasion and the viability of the gestation. Any disturbance or disruption of their normal function in any pregnancy could lead to adverse reproductive outcomes.

About this question:

Is there a connection between NK cells level and miscarriage rate?

Natural killer cells play a crucial role in our life and the majority of us do not think about the importance of immunology. The problem is when the immune system do not work properly.

Find similar questions:

Related questions

Is IVIg the same as Intralipid?

Dimitris Papanikolaou

Dimitris Papanikolaou, MD
Gynaecologist

Watch answers »

How do I know if I have high NK cells?

Dimitris Papanikolaou

Dimitris Papanikolaou, MD
Gynaecologist

Watch answers »

Can immune system cause infertility?

Dimitris Papanikolaou

Dimitris Papanikolaou, MD
Gynaecologist

Watch answers »

Can autoimmune disease cause infertility?

Wael Saab

Wael Saab, MRCOG, Bsc
Gynaecologist

Watch answers »

What are natural killer cells in pregnancy?

Dimitris Papanikolaou

Dimitris Papanikolaou, MD
Gynaecologist

+ 1 more answers

Watch answers »

Can you get pregnant with high natural killer cells?

Orestis Tsonis

Orestis Tsonis, MD, MSc, PhD
Gynaecologist

Watch answers »
Free Download
Fertility Road Magazine
The only magazine devoted to IVF and donor conception!​
15 articles & 68 pages of "All About IVF"