Can PGS/ PGT-A damage embryos?

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1 fertility expert(s) answered this question

Answer from: Raúl Olivares, MD

Gynaecologist, Medical Director & Owner Barcelona IVF
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So far, all the information that we have about the safety of PGS when it is done on day 5 suggests that at least regarding the implantation rates, there are no drawbacks if you take those 3-5 cells we usually take during the biopsy.

It’s true that when PGS was initially done on day 3, the information we had suggested as well it was a safe procedure, we later found out that was not true. The embryos that were biopsied on day 3 showed a 40% lower implantation rate than those that were not biopsied. Taking into account that the cells that we are now studying are the cells that are coming from a structure that is going to be the placenta, which means we don’t touch the inner cell mass, which is going to be the proper embryo later. Therefore, I feel that this kind of biopsy is much safer.

There was one study that compared the implantation rates of the embryos, with doing the biopsy or without doing the biopsy. The result of that study suggested that the embryos were implanted at the same rate. There were no differences.

It’s true that nowadays, the amount of information that we have is not that much because PGS is not such old technology. Probably, we now can confirm that for these 15-20 years that it has been done, it is a safe procedure, and the babies that are born after PGS do not show any higher risk of any kind of health issues.

I really think that PGS done on day 5 is a safe procedure for the embryos, and it does not have any mid-, or long-term side effects.

About this question:

Is there any possibility the PGS - the embryo biopsy may have an impact on embryo quality?

Preimplantation Genetic Testing for Aneuploidies (PGT-A), also known as PGS (Preimplantation Genetic Screening) is a genetic test, which is designed to examine embryos for chromosomal abnormalities, and that way helps to select the best embryos to transfer.  Is PGS/PGT-A safe for the embryo? Does Genetic Testing damage embryos?

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