Answer from:
In normal circumstances, 90% of the embryos that we get on day-1 should reach day-3, and if they don’t, it tends to be because there is probably an egg factor. As a general rule, though it’s something that should be discussed in each case, we consider that the embryo in the first 3 days leaves from what it gets from the egg. The DNA of the sperm is activated on day 3. If you have embryos with problems during the first three days of development, it’s mostly due to the egg quality. If the embryos reach day 3, and they suddenly get worse, this is something that can’t be due to a problem related to the sperm or the male DNA. Of course, that means that if you are 42-43, you may start having very poor quality embryos from day 2, but if you are dealing with a male factor or with a tubal factor, and you are young, I would say that between 90 or even 100% of the embryos with different qualities should make it to day 3.
The main problem and the most critical day for the embryos is day 4 to day 5. That’s why considering to transfer on day 3, should never be done. You may be transferring embryos that look great on day 3, but they are not going to become a blastocyst. I’ve seen in some cases, patients who have been asked for different implantation tests and have never had a single blastocyst. They have always had transfers before. In these cases, likely the main problem is that those embryos didn’t become a blastocyst, and then it would have been unnecessary to carry out any implantation issues.
Whenever you can, take the embryos to day 5, even if they don’t make it to day 5, it’s going to be really useful. I prefer not to transfer the embryos without knowing the real quality. If I only have 1 embryo and I take it to the blastocyst stage, and it does not become a blastocyst, there’s going to be bad news anyway for the patient, but at least, we are going to be sure that the problem is in the embryos, and we are not going to waste time and money asking for implantation tests that are not needed at all.
Answer from:
It all depends on clinical scenario, the age of the patient, the age of male and if there are any problems related with IVF like any chromosomal abnormalities in any of the patient- I mean male or female. Roughly about 50 % of eggs will develop into day 3 embryos and at around 20-25% of eggs will reach the blastocyst stage at day 5.
Answer from:
In terms of numbers, we do expect on the eggs about 80 to 85 % of maturation of the eggs and then out of those 80, 85% we do expect about 75 to 80% of them or 85% even to be fertilised. There’s a bit of a drop off. There’s less of a drop-off when the embryos go to day 3. From my experience I can tell that almost every embryo can make it to day 3. There’s not a huge drop off once they’re fertilised to go to day 3 but there is a huge drop-off though from day 3 until day 5. Some of the embryos they block at day 3 and they cannot go to day 5. There is a bigger drop off from day 3 to day 5.
